Searching through the websites I could find for "San Diego real estate" and "San Diego homes for sale" on Google and Yahoo!, I wasn't really able to find much in the way of information---the non-commercial kind.
What I found however, is that Home Sales San Diego, the self-acclaimed "San Diego Real Estate Insider" is a little different. There wasn't much salesy-speak or pushing of 1-800 numbers of agents, etc. There was more of an informational angle which was pretty refreshing. I gathered that it may or may not be the site of an agent or brokerage, possibly just someone with a real estate background writing about what they know and collecting home buyer and seller leads.
Clicking around I found a good deal of San Diego neighborhood information with statistics and demographics and such, some San Diego realtor interviews, and some more specific blog posts about real estate in various areas (Pacific Beach real estate for example).
I like the blog format, it's nice that there is an active channel for discussion. I also like the fact that there are tips and helpful advice for buyers and sellers and not just a bunch of templated "La Jolla real estate is great to buy and sell", "Del Mar real estate is great to buy and sell" type of doorway pages (I actually came across a site using those while searching Yahoo). Oh, and the graphic design is pretty cool too.
What I find the site is lacking in is content. Maybe it's somewhat new, didn't really check... but it seems to need another 40 or so posts to really fill itself out, and to become a more complete resource for the areas of San Diego which it intends to cover. I think that a higher frequency of posting would allow it to attract an actual following (agents and local amateurish investors could benefit) via RSS, etc. I would also say to keep it up with the real estate agent interviews, that's definitely something that allows potential buyers and sellers a way to preview realtors' personalities a bit more than their own sites usually allow for.
Let us know if there is anything you would add to this review.